MRI is the best and safest way to adequately evaluate the pituitary gland. For all pituitary and supra-sellar lesions, MRI offers multiplanar capabilities and soft tissue contrast essential in detecting these lesions. The large tumors (meningiomas and macro-adenomas) pose no imaging problem. Microadenomas, small enough to exist within the substance of an otherwise normal gland without distorting its contour, may be more difficult to detect. In order to achieve contrast distinction between normal gland and adenoma, dynamic contrast imaging has proven effective. This relies on differential enhancement and washout patterns between most adenomas and normal pituitary tissue.